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第一部分 奋斗历程1

我的科研历程3

天然来源的抗肿瘤药物研究与开发的典范9

第二部分 学术贡献15

一、甄永苏院士的主要学术论文17

五种抗肿瘤药物对小鼠各种组织损害作用的比较17

N-甲酰溶肉瘤素对小鼠精原细胞的损害作用26

小鼠各种组织细胞对N-甲酰溶肉瘤素敏感性的比较——病理形态和细胞计数的研究34

The Murine Spermatogonial Depletion Assay as A Method for Primary Screening of Antitumour Substances41

抗肿瘤药物初筛方法——精原细胞法和噬菌体法的比较研究53

争光霉素A5和争光霉素A2的抗肿瘤作用与毒性研究61

Dexamethasone Synergistically Induces Chemotactic Peptide Receptor Expression in HL-60 Cells69

A Human Granulocyte-Specific Antigen Characterized by Use of Monoclonal Antibodies79

Effects of Acivicin and Dipyridamole on Hepatoma 3924A Cells88

Amphotericin B Renders Stationary Phase Hepatoma Cells Sensitive to Dipyridamole94

抗CCT2单克隆抗体和争光霉素A6结合物的抗白血病细胞活性98

博来霉素A6抗人体肝癌的实验研究102

Amphotericin B: A Biological Response Modifier in Targeting Against the Salvage Pathways107

A New Macromolecular Antitumor Antibiotic, C-1027 Ⅲ. Antitumor Activity114

Potentiation of Antimetabolite Antitumor Activity in Vivo by Dipyridamole and Amphotericin B119

Mode of Action of C-1027, A New Macromolecular Antitumor Antibiotic With Highly Potent Cytotoxicity, on Human Hepatoma BEL-7402 Cells127

博来霉素A6对小鼠肺毒性的电子显微镜观察136

Green Tea Extract Inhibits Nucleoside Transport and Potentiates the Antitumor Effect of Antimetabolites141

Azidothymidine and Dipyridamole as Biochemical Response Modifiers: Synergism with Methotrexate and 5-Fluorouracil in Human Colon and Pancreatic Carcinoma Cells148

Antitumor Activity of Immunoconjugates Composed of Boanmycin and Monoclonal Antibody156

Novel Nucleoside Transport Inhibitors of Natural Origin162

A Single Binding Mode of Activated Enediyne C1027 Generates Two Types of Double-Strand DNA Lesions: Deuterium Isotope-Induced Shuttling Between Adjacent Nucleotide Target Sites164

Antibiotic C3368-A, A Fungus-Derived Nucleoside Transport Inhibitor, Potentiates the Activity of Antitumor Drugs179

Induction of Apoptosis by Enediyne Antitumor Antibiotic C1027 in HL-60 Human Promyelocytic Leukemia Cells186

Antitumor Activity of Yunnanmycin A Novel Pyrimidine Nucleoside Antibiotic191

Antitumor Components From an Actinomycete Strain 6011W195

Cinnamamide, an Antitumor Agent With Low Cytotoxicity Acting on Matrix Metalloproteinase199

Intracellular Expression of A Single-Chain Antibody Directed Against Type Ⅳ Collagenase Inhibits the Growth of Lung Cancer Xenografts in Nude Mice204

Activity of Boanmycin Against Colorectal Cancer210

大黄素抑制人高转移巨细胞肺癌PG细胞的肿瘤转移相关性质217

Antitumor Effects of Monoclonal Antibody Fab′ Fragment-Containing Immunoconj ugates224

Antitumor Effects of the Molecule-Downsized Immunoconjugate Composed of Lidamycin and Fab′ Fragment of Monoclonal Antibody Directed Against Type Ⅳ Collagenase230

HERG K+ Channel Expression-Related Chemosensitivity in Cancer Cells and Its Modulation by Erythromycin239

An Enediyne-Energized Single-Domain Antibody-Containing Fusion Protein Shows Potent Antitumor Activity250

Down-Regulation of the Nuclear Factor-kB by Lidamycin in Association With Inducing Apoptosis in Human Pancreatic Cancer Cells and Inhibiting Xenograft Growth263

Synergy of Gemcitabine and Lidamycin Associated With NF-kB Downregulation in Pancreatic Carcinoma Cells272

Binding Capability of the Enediyne-Associated Apoprotein to Human Tumors and Constitution of A Ligand Oligopeptide-Integrated Protein279

Enediyne Lidamycin Enhances the Effect of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Gefitinib, in Epidermoid Carcinoma A431 Cells and Lung Carcinoma H460 Cells291

Lidamycin Shows Highly Potent Cytotoxic to Myeloma Cells and Inhibits Tumor Growth in Mice301

Rhein Lysinate Suppresses the Growth of Breast Cancer Cells and Potentiates the Inhibitory Effect of Taxol in Athymic Mice310

A Bispecific Enediyne-Energized Fusion Protein Containing Ligand-Based and Antibody-Based Oligopeptides Against Epidermal Growth Factor Receptor and Human Epidermal Growth Factor Receptor 2 Shows Potent Antitumor Activity319

A Tandem ScFv-Based Fusion Protein and Its Enediyne-Energized Analogue Show Intensified Therapeutic Efficacy Against Lung Carcinoma Xenograft in Athymic Mice331

Endostar, A Modified Recombinant Human Endostatin, Exhibits Synergistic Effects With Dexamethasone on Angiogenesis and Hepatoma Growth343

Antitumor Efficacy of the scFv-Based Fusion Protein and Its Enediyne-Energized Analogue Directed Against Epidermal Growth Factor Receptor354

Pingyangmycin Downregulates the Expression of EGFR and Enhances the Effects of Cetuximab on Esophageal Cancer Cells and the Xenograft in Athymic Mice366

An NGR-Integrated and Enediyne-Energized Apoprotein Shows CD13-Targeting Antitumor Activity377

Lidamycin Inhibits Tumor Growth and Pulmonary Metastasis in Murine Breast Carcinoma and Shows Synergy With Paclitaxel387

抗肿瘤导向药物研究的现状与展望396

天然来源的新型抗肿瘤生化调节剂405

抗肿瘤抗生素和治疗肿瘤的单克隆抗体药物408

抗体药物靶向治疗肿瘤前景广阔419

抗肿瘤抗生素平阳霉素研究与临床应用40年423

二、甄永苏院士的主要学术著作429

TEA429

抗体工程药物446

抗体药物研究与应用464

抗肿瘤药物研究与开发475

三、甄永苏院士学术年表520

个人简历520

甄永苏院士论文目录521

甄永苏院士参加的主要学术会议与报告540

甄永苏院士著作目录546

甄永苏院士培养研究生名录548

甄永苏院士已获授权的专利项目553

第三部分 治学之道557

科技创新的认识与实践559

勤奋 敬业 乐群562

沙里淘金费苦辛 药中奥妙细追寻——记中国工程院院士甄永苏教授565

甄永苏：科研贵在创新567

第四部分 大师风范571

甄永苏院士——我们的良师益友573

写在甄永苏院士从业60周年前夕576

在甄永苏老师身边学习和工作的日子580

在甄老师身边多年的一些感悟582

回忆甄老师指导我如何作好科研报告584

我认识的甄老师586

在院士身边做博士588

尊敬的师长，真正的大师590

与甄永苏院士的师生缘592

桃李芬芳引路人 青丝华发闪师恩593

上善若水，大爱无痕594

第五部分 人生风采597

美满家庭599

校友情深602

学科建设604

学术活动606

国际交流609

重要时刻611

院士活动613